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Obesity-Driven Gut Microbiota Inflammatory Pathways to Metabolic

Nov 19, 2015 ... inflammation associated with obesity and metabolic syndrome. Inflammatory .... Epithelial (e.g., enterocytes and goblet cells) and endocrine cells ..... FIGURE 2 | Adipocytes-infiltrating immune cell profile in lean and obese individuals and relationship between gut microbiota, insulin sensitive organs,.


Consideration of the evidence on childhood obesity for the

May 5, 2016 ... 2. WHO Library Cataloguing-in-Publication Data. Consideration of the evidence on childhood obesity for the Commission on Ending. Childhood Obesity: report of the ad hoc working group on ... of any opinion whatsoever on the part of the World Health Organization concerning the legal status of any.


Hypothalamic Inflammation in Human Obesity is Mediated by

Jun 2, 2017 ... factors. Short title: Hypothalamic inflammation in human obesity. Carina Kreutzer. 1. , Sönke Peters. 2. , Dominik M. Schulte. 1. , Daniela Fangmann. 1 ... disturbances in the gut-brain axis which are influenced by both environmental and genetic ..... Neuroimaging clinics of North America 2013;23:359-380.


Intestinal microbiota, probiotics and mental health: from Metchnikoff

Mar 14, 2013 ... metchnikoff to modern advances: part II – contemporary contextual research. Gut Pathogens 5: 3. Published Version doi:10.1186/1757-4749-5-3 .... Although the gut- microbiota-brain connection may ultimately extend clinic- ally to diverse conditions, from autism to schizophrenia. [11,12], for the purposes of ...


Regulation of Appetite, Satiation, and Body Weight by

Jan 14, 2015 ... Weight by Enteroendocrine Cells. Part 2: Therapeutic Potential of Enteroendocrine Cells in the Treatment of Obesity. Carsten Posovszky a Martin Wabitsch b. aUniversity Outpatient Clinic for Pediatric Gastroenterology and bDivision of Pediatric Endocrinology and Diabetes,. Department of Pediatrics and  ...


The influence of probiotic supplementation on gut permeability in

Aug 8, 2012 ... BACKGROUND/OBJECTIVES: Obesity and metabolic disorders are linked to inflammation via gut microbiota and/or gut ... Department of Internal Medicine, Division of Endocrinology and Metabolism, Cardiovascular Diabetology Research Group, Medical University of Graz, Auenbruggerplatz 15,. Graz 8010 ...


Insights Into the Role of the Microbiome in Obesity and Type 2

The worldwide prevalence of obesity and type 2 diabetes mellitus (T2DM) continues to rise at an alarming pace. Recently the potential role of the gut microbiome in these metabolic disorders has been identified. Obesity is associated with changes in the composition of the intestinal microbiota, and the obese microbiome ...


Lysine acetylation in obesity, diabetes and metabolic disease

Nov 15, 2011 ... Lysine acetylation is vitally important in both immunological and metabolic pathways and may regulate the balance between energy storage and expenditure. Obesity, type II diabetes and cardiovascular disease (metabolic syndrome) are widely recognised as features of a chronic low-grade inflammatory.


Metabolic syndrome: is equine disease comparable to what we

Furthermore, this article provides insights and focuses on issues concerning laminitis in horses and cardiovascular diseases in humans, as well as their overlap. Key Words. " metabolism. " obesity. " diabetes. " cardiovascular. " inflammation. Endocrine Connections. (2014) 3, R81–R93. Introduction. Metabolic syndrome in ...


Is eating behavior manipulated by the gastrointestinal microbiota

between host and microbes leads to host manipulation. The struggle to resist cravings for foods that are high in sugar and fat is part of daily life for many people. Unhealthy eating is a major contributor to health problems including obesity [1] as well as sleep apnea, diabetes, heart disease, and cancer [2–4]. Despite negative ...


Endocrine Abstracts vol 41

May 28, 2016 ... N Pitteloud Switzerland. M Poutanen .... Gut microbiota, inflammation and metabolism (Endorsed by Endocrine Connections) . .... Strengths and weaknesses of hormone immunoassays and mass spectrometry: what the clinician should know. D3.1–D3.2. Are we ready for pharmacological therapy of obesity?


Endocrinology of the gut

Mar 14, 2016 ... just be acting in service of the controlling army of gut microbes that are making their presence felt in almost all ... 19 Obesity and Metabolic Endocrine ..... or to the vagus nerve, which is another important relay connecting the intestines with endocrine brain centres such as the hypothalamus. (Figure 2). In fact ...


Autonomic Nervous System in the Control of Energy Balance and

Mar 24, 2013 ... The prevalence of obesity is increasing in the industrialized world, so that the World Health Organization considers obesity as a “pandemia” in ... various origins (e.g., gut, hepatoportal area, baroreceptors) are integrated in ..... ease,” Endocrinology and Metabolism Clinics of North America, vol. 32, no. 4, pp ...


Dietary intervention rescues maternal obesity induced behavior

Sep 12, 2014 ... Maternal obesity-induced changes in offspring brain lipid peroxidation, hippocampal neurogenesis, and inflammation [12]-[14] may also impact ... in the three-chamber social interaction assay, revealed no significant correlation between litter size and behavior (linear regression R2 = 0.02557, P = 0.177).


The Microbial Hypothesis: Contributions of Adenovirus Infection and

Oct 25, 2016 ... It is now debated whether infection and endotoxaemia are also implicated in initiating and perpetuating low grade inflammation. ... this basis that Massachusetts General Hospital is sponsoring the Faecal Microbiota Transplant for Obesity and Metabolism clinical .... The adipocyte plays a key endocrine.


Gut Microbiota in Cardiovascular Health and Disease

Mar 31, 2017 ... disease, obesity, and type 2 diabetes mellitus. ... metabolic potential of gut microbiota has been identified as a contributing factor in the development of ... Links Between Gut Microbiota and Cardiometabolic Diseases. Atherosclerosis. Hypertension. Heart Failure. Obesity, T2DM. Chronic Kidney Disease.


Concentrations with Metabolic Syndrome in Extremely Obese Subjects

Obesity may influence the metabolic expression of circulating PYY3-36 and metabolic markers. We studied the relationship of PYY3-36 concentrations with ... components, lipids, insulin resistance, and inflammatory biomarkers in subjects with extreme obesity. ... in part, to improvements in other risk factors.3 Persons with.


The gut microbiome: the role of a virtual organ in the endocrinology

Jul 5, 2013 ... gut microbiome. " endocrine system. Journal of Endocrinology. (2013) 218, R37– R47. Introduction. In the many years of studying the human body, it has .... Bile metabolism and gut bacteria. Bile acids/salts are cholesterol-derived host metabolites that play a role in several host processes (Fig. 2). Their.


Gut Microbiota and Nonalcoholic Fatty Liver Disease: Insights on

Mar 15, 2016 ... as dysregulation of energy homeostasis, insulin resistance, inflammation, and choline and bile acid metabolism. Metabolomics is a ... 2. The Gut Microbial Mechanism of NAFLD. 2.1. Gut Microbiota and Host Energy Metabolism. Obesity is the basis of most metabolic diseases. Gut microbiota play important ...


The Role of the Endocannabinoid System in the Brain-Gut Axis

The actions of cannabis are mediated by receptors that are part of an endogenous cannabinoid system. The endo- cannabinoid system (ECS) consists of the naturally occur- ring ligands N-arachidonoylethanolamine (anandamide) and 2-arachidonoylglycerol (2-AG), their biosynthetic and degradative enzymes, and the ...