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Epigenetic mechanisms in the development and maintenance of
dynamic manner in which epigenetic mechanisms are coordinated and regulate gene ... impact human health and disease. Epigenetics in mdDA ..... Bdnf. Nurr1. DNA methylation. Histone acetylation. Key. Fig. 3. The effects of extracellular signals on epigenetic programming in dopaminergic and other neuronal cell models.
PRC1-Mediated Gene Silencing in Pluripotent ES Cells: Function
of PRC1 for the establishment and maintenance of embryonic stem (ES) cell pluripotency with special emphasis on the evolution of ... Berlin Heidelberg 2015. A. Meissner, J. Walter (eds.), Epigenetic Mechanisms in Cellular Reprogramming ,. Epigenetics and Human Health, DOI 10.1007/978-3-642-31974-7_7. 141 ...
Child Health, Developmental Plasticity, and Epigenetic Programming
Plasticity in phase transitions of human life history. Epigenetic Programming and Developmental Plasticity. The epigenome. The epigenetic marks. Reading the epigenetic marks and developmental and physiological consequences. Epigenetics as a molecular mechanism for developmental origins of disease. Heritability of ...
Epigenetics: a new frontier in dentistry
In 2007, only four years after the completion of the Human Genome Project, the journal Science announced that epige- netics was the .... including oral health. Epigenetic changes are a poten- tial mechanism contributing to these changes. The findings from a large community based study in the. USA suggest that the DNA ...
Induced pluripotent stem cells reprogramming: Epigenetics and
Keywords:induced pluripotent stem cells, regenerative medicine, cell reprogramming, epigenetics, histones, microRNAs. INTRODUCTION. Human embryonic stem cells have great potential for self-renewal and the ability to differentiate into .... DNA methylation is an epigenetic mechanism involved in many important cellular ...
Stem Cell Epigenetics: Looking Forward
Jun 5, 2014 ... stem cell heterogeneity is rather recent, I am interested in exploring its significance in health and disease. For instance, which epigenetic factors determine when and how different stem cell populations are established? What mechanisms prevent their intermingling in healthy tissues but allow for their ...
Understanding Epigenetic Memory is the Key to Successful
Loss of Dnmts can cause severe deformities and death, indicating that proper epigenetic DNA methylation patterns are essential to development and health. .... 49 human cell lines were examined to compare the expression levels of 330 miRNAs (466 in some cases) across hESCs, differentiated cells, hiPSCs, and cancer ...
Age-related epigenetic drift and phenotypic plasticity loss
Nov 24, 2016 ... Keywords: aging • chromatin • DNA methylation • environment • epigenetic drift ... are now generally accepted that impaired epigenetic hallmarks contribute to biological aging, chronological age and aging-associ- ated disorders. However .... Environmental factors affect cell function through direct or indirect.
What obesity research tells us about epigenetic mechanisms
of cell divisions. However, the silenced X-chromosome has to be reactivated between generations so that a female can produce a healthy male child. This reactivation occurs in the cells that are the precursors of the gametes in a process of genome-wide transgenerational epigenetic reprogramming. (see below) [13, 15].
Epigenetics in formation, function, and failure of the endocrine
May 31, 2017 ... Beyond their role in cell differentiation, interactions of the organism with the environment are also often encoded into permanent or semi-permanent epigenetic marks and affect cellular behavior and organismal health. Epigenetics is defined as any heritable e at least through one mitotic cell division e ...
Epigenetic mechanisms during ageing and neurogenesis as novel
Keywords: Epigenetics, DNA methylation, Histone modifications, Epidrug, Neurogenesis, Neurodegeneration,. Psychiatric disorders. Background. Ageing, defined as the progressive functional decline of organisms at molecular, cellular and physiological level, is the main risk factor for major human diseases such as cancer ...
Use of Human Neurons Derived via Cellular Reprogramming
Sep 23, 2017 ... Human neurons derived from somatic cells via cellular reprogramming methods such as human ... necessarily recapitulate the human phenotype of neurological disorders due to inherent structural, .... and the epigenetic mechanisms underlying reprogramming are not yet fully understood, but clearly a.
Medaka as a model for studying environmentally induced epigenetic
worms, fish, and mammals, indicating that exposures affect not only human health but also fish and ecosystem health. ... contaminant exposure in various models, associated epigenetic mechanisms, and a perspective on fish as model to study ..... erasure of DNA methylation marks gives rise to a stem cell state for PGCs ...
Feb 24, 2010 ... Environmental Health, Exposure, Epidemiology and Risk Program, Harvard School of Public Health, Boston, MA, USA. Epigenetics investigates heritable changes in gene expres- sion that occur without changes in DNA sequence. Several epigenetic mechanisms, including DNA methylation and.
A Concise Review on Epigenetic Regulation: Insight into Molecular
Nov 30, 2011 ... In this review, firstly, regulatory epigenetic mechanisms related to somatic cell nuclear transfer (SCNT) reprogramming are discussed, followed by embryonic development, and placental epigenetic issues. Keywords: epigenetic; pluripotency; SCNT; embryogenesis; gametogenesis; polycomb; methylation ...
Non-genomic transmission of longevity between generations
Jul 21, 2017 ... Increas- ing evidence suggests a central role of epigenetic mechanisms ( heritable alterations in gene expression occurring ... Keywords: Epigenetics, DNA methylation, Transgenerational inheritance, Aging, Age-associated disease, Longevity .... factors important for cell reprogramming during devel-.
Information -sharing, adaptive epigenetics and human longevity
evolution of aging in general. Increasingly, research shows that the environment is crucial in determining prolonged healthy longevity . In human terms, the ... based on the fact that epigenetic processes can regulate mechanisms necessary ... of these break factors and thus allow for easier and quick plasticity of the cell.
Jun 2, 2017 ... National Institutes of Health • U.S. Department of Health and Human Services .... Principles of Epigenetics and Chromatin in Development and Human Disease. 3: 00 – 5:00 p.m.. POSTER ..... and Human Disease”. Epigenetic regulation of gene expression in metazoans is central for establishing cellular.
EFSA Scientific Colloquium N°22 'Epigenetics and Risk Assessment
health, animal health and environmental risk assessment of chemicals. ... epigenetics mechanisms and the potential use and integration of epigenetic data ... Cell, 153: 56-69. Lalevee, S., & Feil, R. 2015. Long noncoding RNAs in human disease: emerging mechanisms and therapeutic strategies. Epigenomics, 7: 877- 879.
INTERNATIONAL HUMAN EPIGENOME CONSORTIUM
Reprogramming involves ... health and diseases. 2. IHEC will focus on key cellular states such as stemness, immortality, proliferation, differentiation, senescence, and stress, thereby generating new knowledge that will catalyse ... consortia that focus on central epigenetic questions such as DNA methylation ( HEP, Human.