KERIS: The kaleidoscope of gene responses to inflammation among species. A cornerstone of modern biomedical research is the use of mouse models to explore basic disease mechanisms, evaluate new therapeutic approaches, and make decisions to carry new drug candidates forward into clinical trials. However, few of these human trials have shown success. We reported previously that, although acute inflammatory stresses from different etiologies result in highly similar genomic responses in humans, the response of murine ortholog genes poorly correlate with their human counterparts in inflammatory diseases.
A vibrant discussion of the merits and limitations of animal models is long overdue. In order to help the research community to better explore the similarities and differences of genomic response between human diseases and murine models and to better translate findings from disease models to human studies, we developed this genomic response database of human inflammatory diseases. As of June 2016, KERIS includes comparisons of the genomic response of 6 human inflammatory diseases and conditions (Burns, Trauma, Infection, Sepsis, Endotoxin and Acute Respiratory Distress Syndrome) and matched mouse models, using 2,257 curated samples from the Inflammation and the Host Response to Injury Glue Grant studies and other representative studies in Gene Expression Omnibus. A researcher can browse, query, visualize, and compare the response patterns of genes, pathways, and functional modules across different diseases and corresponding murine models. Read More