Genomic Storm in White Blood Cells of Trauma Patients

Introduction and Background Human survival from injury requires an appropriate inflammatory and immune response. We describe the circulating leukocyte transcriptome after severe trauma and show that these severe stresses produce a global reprioritization affecting >80% of the cellular functions and pathways, a truly unexpected “genomic storm.” In severe blunt trauma,…

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Time course multifactor analysis

Description Time-course microarray experiment is capable of capturing the dynamic profile of genomic response to treatment factors. The profile contains valuable information for researchers to identify possible genetic factors that lead to different clinical outcomes, which can help directing future investigation. We developed a general statistical method to extract gene-specific…

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