Genomic Storm in White Blood Cells of Trauma Patients

Introduction and Background Human survival from injury requires an appropriate inflammatory and immune response. We describe the circulating leukocyte transcriptome after severe trauma and show that these severe stresses produce a global reprioritization affecting >80% of the cellular functions and pathways, a truly unexpected “genomic storm.” In severe blunt trauma,…

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Resources

GG-H Array: Glue Grant Human Transcriptome Arrays A high-throuhgput and cost-effective platform for clinical genomics The Human Genomic Response to Severe Traumatic Injury An interactive website for exploring gene expression in white blood cells of trauma patients and their selected clinical attributes. JETTA: Junction and Exon array Toolkit for Transcriptome…

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Time course multifactor analysis

Description Time-course microarray experiment is capable of capturing the dynamic profile of genomic response to treatment factors. The profile contains valuable information for researchers to identify possible genetic factors that lead to different clinical outcomes, which can help directing future investigation. We developed a general statistical method to extract gene-specific…

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People

Weihong Xu, weihongx-at-stanford.edu Claire Ryu, clairesr-at-stanford.edu Amit Kaushal, akaushal-at-stanford.edu Junhee Seok, jseok-at-stanford.edu Hong Gao, hgao98-at-stanford.edu Jaclyn Chen, Jaclync-at-stanford.edu Wenzhong Xiao, wzxiao-at-stanford.edu Collaborators Wing H Wong, Stanford University Rob Tibshirani, Stanford University John Storey, Princeton University David Scheonfeld, Massachusetts General Hospital Further Information The Computational Biology Group at the Stanford Genome…

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Publications

    Huber, C.G., Premstaller, A., Xiao, W., Oberacher, H., Bonn, G.K., and Oefner, P.J. (2001). Mutation detection by capillary denaturing high-performance liquid chromatography using monolithic columns. J Biochem Biophys Methods 47, 5-19. Premstaller, A., Xiao, W., Oberacher, H., O’Keefe, M., Stern, D., Willis, T., Huber, C.G., and Oefner, P.J.…

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Welcome!

The research of our computational genomics group at Stanford Genome Technology Center aims at pushing the boundaries of genomics technology from base pairs to bedside. At the center, our group is closely involved in the development of biotechniques from their early stage pilot studies to the demonstration applications. We use…

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